Статья 5222

Title of the article

Trilemma of magnetic hyperthermia “field – frequency – size” by the example of ZnMn ferrite nanoparticles 

Authors

Nan Nan Liu, Postgraduate student, Lomonosov Moscow State University (1 Leninskiye Gory street, Moscow, Russia), E-mail: nannan.liu@irlc.msu.ru
Aleksandr P. Pyatakov, Doctor of physical and mathematical sciences, professor of the sub-department of physics of oscillations, Lomonosov Moscow State University (1 Leninskiye Gory street, Moscow, Russia), E-mail: pyatakov@physics.msu.ru
Nikolay A. Pyataev, Doctor of medical sciences, associate professor, head of the sub-department of anesthesiology and resuscitation with courses in valeology, life safety and disaster medicine, Orgarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: pyataevna@mail.ru
Gleb B. Sukhorukov, Doctor of physical and mathematical sciences, professor, Skolkovo Institute of Science and Technology (30 Bolshoy boulevard, Moscow, Russia); Queen Mary University of London (Mile End Road London E1 4NS), E-mail: g.sukhorukov@qmul.ac.uk
Aleksandr M. Tishin, Doctor of physical and mathematical sciences, professor, professor of the sub-department of general physics and condensed state physics, Lomonosov Moscow State University (1 Leninskiye Gory street, Moscow, Russia), E-mail: tishin@amtc.org 

Abstract

The efficiency of conversion of electromagnetic energy into heat is a key factor for magnetic nanoparticles (MNPs) utilization in magnetic hyperthermia and many other emerging medical technologies, such as treating Parkinson’s disease and MNP-based nerve interface. At present, in order to increase the release of heat, the concentration and/or EM field of the MNPs in tumors increased, which increases the weight, size and power consumption of the field source, and the increase in the adverse effects of the health organization. In this review, we first proposed the dilemma of magnetic hyperthermia for the first time. The best balance between the frequency, amplitude and MNP size of the electromagnetic field is determined. The purpose of the work is to try to use MnZn iron oxygen MNP as an example to solve this dilemma. That is to find the best combination of MNP features and external parameters, and develop a new strategy that uses MnZn iron oxygen -based MNP to improve heat dissipation efficiency at a lower frequency. Research in the field of magnetic hyperthermia will be focused on the new range of magnetic field amplitude and MNP sizes. The paper shows the extraordinary dependence of EM field in Zn0.2Mn0.8Fe2O4 MNP (nearly five, not well-known the second-power one). Our study challenges the traditional approach based on minimizing the magnetic field and increasing the frequency (in some cases up to 300–500 kHz or even higher) and suggests an improved strategy: increasing the amplitude while decreasing the frequency as much as possible. This will make it possible to effectively use the presence of a superquadratic dependence of the specific absorption of EM energy on the field amplitude in MNPs. The results of the study may have a significant impact on the development strategy of other advanced biomedical technology using MNPs. 

Key words

magnetic hyperthermia, specific absorption rate, magnetic nanoparticles, internal loss power, hysteresis mechanism 

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For citation:

Liu N.N., Pyatakov A.P., Pyataev N.A., Sukhorukov G.B., Tishin A.M. Trilemma of magnetic hyperthermia “field – frequency – size” by the example of ZnMn ferrite nanoparticles. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Fizikomatematicheskie nauki = University proceedings. Volga region. Physical and mathematical sciences. 2022;(2):54–80. (In Russ.). doi:10.21685/2072-3040-2022-2-5

 

Дата создания: 16.09.2022 15:20
Дата обновления: 06.10.2022 08:37